田中（賢）研究室

A. 学術論文情報（Papers）

1. Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates

M. Nomura, Y.  Yokoyama, D. Yoshimura, Y. Minagawa, A. Yamamoto, Y. Tanaka, N. Sekiguchi, D. Marukawa, M. Ichihara, H. Itakura, K. Matsumoto, Y. Morimoto, H. Tomihara, A. Inoue, T.  Ogino, N.  Miyoshi, H. Takahashi, H. Takahashi, M. Uemura, S. Kobayashi, T. Mizushima, T.  Anada, M. Mori, Y. Doki, M. Tanaka, H. Eguchi, H. Yamamoto*
Int. J. Mol. Sci., 24(4), 3949 (2023)
https://doi.org/10.3390/ijms24043949

2. Honeycomb-like structured film, a novel therapeutic device, suppresses tumor growth in an in vivo ovarian cancer model

T. Ohta*, M. Tanaka, S. Taki, H. Nakagawa, S. Nagase
Cancers, 15(1), 237 (2023)
https://doi.org/10.3390/cancers15010237

3. Effect of titanium-doped bioactive glass on poly(2-hydroxyethyl methacrylate) hydrogel composites: bioactivity, intermediate water, cell proliferation, and adhesion force Modulation Atomic Force Microscopy

M. Mabrouk*, H. H. Beherei, S. Shiomoto, Y. Tanaka, L. Osama, M. Tanaka*
Ceramics International, in press.
https://doi.org/10.1016/j.ceramint.2022.12.221

4. Comparative Study of PEG and PEGylated Dendrimer in their Eutectic Mixtures of Water Analyzed using X-ray Diffraction and Infrared Spectroscopy

C. Kojima*, Y. Suzuki, Y. Ikemoto, M. Tanaka, A. Matsumoto
Polymer Journal, 55, 63–73 (2023)
https://doi.org/10.1038/s41428-022-00700-5

5. Alkyl chain length-dependent protein nonadsorption and adsorption properties of crystalline alkyl β-celluloside assemblies

T. Serizawa*, S. Yamaguchi, M. Amitani, S. Ishii, H. Tsuyuki, Y. Tanaka, T. Sawada, I. Kawamura, G. Watanabe, M. Tanaka
Colloids and Surfaces B: Biointerfaces, 220, 112898 (2022)
https://doi.org/10.1016/j.colsurfb.2022.112898

6. Enrichment of cancer cells based on antibody-free selective cell adhesion

S. Kobayashi*, A. Sugasaki, Y. Yamamoto, Y. Shigenoi, A. Udaka, A. Yamamoto, M. Tanaka*
ACS Biomaterials Science & Engineering, 8(10), 4547-4556 (2022)
https://doi.org/10.1021/acsbiomaterials.2c00662

7. Simultaneous Control of the Mechanical Properties and Adhesion of Human Umbilical Vein Endothelial Cells to Suppress Platelet Adhesion on a Supramolecular Substrate

J. Park, T. Ueda, Y. Kawai, K. Araki, M. Kido, B. Kure, N. Takenaka, Y. Takashima*, M. Tanaka*
RSC Advances, 12(43), 27912-27917 (2022)
https://doi.org/10.1039/d2ra04885j

8. Cell Adhesion Strength Indicates the Antithrombogenicity of Poly(2-Methoxyethyl Acrylate) (PMEA): Potential Candidate for Artificial Small-Diameter Blood Vessel

M. A. Haque, D. Murakami*, M. Tanaka*
Surfaces, 5(3), 365-382 (2022)
https://doi.org/10.3390/surfaces5030027

9. Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates

Y. Watanabe, S. Takaoka, Y. Haga, K. Kishi, S. Hakozaki, A. Narumi, T. Kato, M. Tanaka, K. Fukushima*
Polymer Chemistry, 13(36), 5193-5199 (2022)
https://doi.org/10.1039/d2py00705c

10. Poly(2-methoxyethyl acrylate)(PMEA)-coated anti-platelet adhesive surfaces to mimic native blood vessels through HUVECs attachment, migration, and monolayer formation

M. A. Haque, D. Murakami*, T. Anada, M. Tanaka*
Coatings, 12(6), 869 (2022)
https://doi.org/10.3390/coatings12060869

11. Characterization of Hydration Water Bound to Choline Phosphate-Containing Polymers

S. Shiomoto, K. Inoue, H. Higuchi, S. Nishimura, H. Takaba, M. Tanaka*, M. Kobayashi*
Biomacromolecules, 23(7), 2999–3008 (2022)
https://doi.org/10.1021/acs.biomac.2c00484

12. Sol-gel silicate glass doped with silver for bone regeneration: Antibacterial activity, intermediate water, and cell death mode

M. Mabrouk*, H. H. Beherei, Y. Tanaka, M. Tanaka*
Biomaterials Advances, 138, 212965 (2022)
https://doi.org/10.1016/j.bioadv.2022.212965

13. Manipulation of Surface Hydration States by Tuning the Oligo(Ethylene Glycol) Moieties on PEDOT to Achieve Platelet-Resistant Bioelectrode Applications

J.-J Huang, C.-H. Lin, Y. Tanaka, A. Yamamoto, S.-C Luo*, M. Tanaka*
Advanced Materials Interfaces, 2200707 (2022)
https://doi.org/10.1002/admi.202200707

14. Infrared Spectra and Hydrogen-Bond Configurations of Water Molecules at the Interface of Water-Insoluble Polymers under Humidified Conditions

Y. Ikemoto*, Y. Harada, M. Tanaka, S. Nishimura, D. Murakami, N. Kurahashi, T. Moriwaki, K. Yamazoe, H. Washizu, Y. Ishii, H. Torii*
The Journal of Physical Chemistry B, 126(22), 4143-4151 (2022)
https://doi.org/10.1021/acs.jpcb.2c01702

15. Surfactant-Free Suspension Polymerization of Hydrophilic Monomers with an Oil-in-Water System for the Preparation of Microparticles Toward the Selective Isolation Tumor Cells

S. Nishimura, K. Nishida*, S. Shiomoto, M. Tanaka*
Materials Advances, 3(12), 5043-5054 (2022)
https://doi.org/10.1039/D2MA00129B

16. Roles of interfacial water states on advanced biomedical material design

K. Nishida, T. Anada, M. Tanaka*
Advanced Drug Delivery Reviews, 186, 114310 (2022)
https://doi.org/10.1016/j.addr.2022.114310

17. Nanoscopic Analyses of Protein Adsorption on Poly(2-methoxyethyl acrylate) Surfaces for Tailoring Cell Adhesiveness

K. Nishida, K. Baba, D. Murakami*, M. Tanaka*
Biomaterials Science, 10(11), 2953-2963 (2022)
https://doi.org/10.1039/D2BM00093H

18. Biocompatible poly(N-(ω-acryloyloxy-n-alkyl)-2-pyrrolidone)s with widely-tunable lower critical solution temperatures (LCSTs): a promising alternative to poly(N-isopropylacrylamide)

S. Nishimura*, K. Nishida, T. Ueda, S. Shiomoto, M. Tanaka*
Polymer Chemistry, 13(17), 2519–2530 (2022)
https://doi.org/10.1039/d2py00154c

19. Effect of Osmolytes on Water Mobility Correlates with Their Stabilizing Effect on Proteins

M. Hishida*, R. Anjum, T. Anada*, D. Murakami, M. Tanaka*
The Journal of Physical Chemistry B, 126, 13, 2466–2475(2022)
https://doi.org/10.1021/acs.jpcb.1c10634

20. Experimental Evidences of Slow Mode Water in the Vicinity of Polyethylene oxide at Physiological Temperature

T. Tominaga*, M. Hishida, D. Murakami, Y. Fujii, M. Tanaka, H. Seto*
The Journal of Physical Chemistry B, 126, 8, 1758–1767 (2022)
https://doi.org/10.1021/acs.jpcb.1c09044

21. Selective Accumulation to Tumor Cells with Coacervate Droplets Formed From Water-Insoluble Acrylate Polymer

K. Nishida*, S. Nishimura, M. Tanaka*
Biomacromolecules, 23(4), 1569–1580 (2022)
https://doi.org/10.1021/acs.biomac.1c01343

B. 総説・解説（Reviews）・著書(Books)

1. 生体親和性を有するテーラーメイド型温度応答性ポリ(N-(ω-アクリロイロキシアルキル)-2-ピロリドン)の設計と合成

日韓バイオマテリアル学会若手研究者交流AWARD受賞論文
西村 慎之介*, 田中 賢バイオマテリアル-生体材料-, 41-1, 24-25 (2023)
 

2. ソフトバイオマテリアル・バイオ界面における水の状態と役割

新・講座 水の化学 Part 2③
田中 賢*化学と教育, 70(7), 348-351 (2022)
 

3. 第II章 バイオマテリアルの種類と医療応用 II-５. 時代をリードする先端バイオマテリアル

田中 賢* ヴィジュアルでわかるバイオマテリアル 改定第4版, Gakken, p.109-110 (2023)
 

4. 第4節 高分子ミセルの細胞内取り込みに対する水和状態の影響

西田 慶, 田中 賢* 
新規モダリティー医薬品のための新しいDDS技術と製剤化, 技術情報協会, p.99-104 (2023)
 

5. 2-B バイオ・医療用, 2-23 抗血栓コート剤

田中 賢*
高分子材料の辞典 Encyclopedia of Polymeric Materials,  高分子学会編, 朝倉書店, p.186-187(2022)
 

6. 第3節 高分子系バイオマテリアル

田中 賢*製品利用に向けたバイオマテリアル開発の基本事項と注意点－材料の特徴・材料劣化・表面解析・安全性試験・ニーズ収集－, 情報機構, p.25-32 (2022)
 

C. 特許情報（Patents）

1. [発明の名称]細胞付着用シート

特許番号: JP-7199065-B2
特許発行日: 2022/12/22
[発明の名称]細胞付着用シート
特開番号: WO-2020153364-A1
公開日: 2020/7/30
[発明の名称] Cell adhesion sheet
特開番号:US-20210332180-A1
公開日:2021/10/28
[発明の名称] Cell adhesion sheet
特開番号: EP3916079A4
公開日:2022/3/23

2. [発明の名称] 特定細胞捕捉方法

特許番号: JP-7170254-B2
特許発行日: 2022/11/14
[発明の名称] Method for capturing specific cells
特開番号: US-20190250149-A1
公開日: 2019/8/15

3. [発明の名称]医療用コーティング剤及び医療機器

特開番号: JP-2022167430-A公開日: 2022/11/4
 

4. [発明の名称]特定細胞捕捉方法

特許番号: JP-7158671-B2
特許発行日: 2022/10/24
[発明の名称]Method for capturing specific cells
特開番号:US-11226330-B2
公開日: 2022/1/18

5. [発明の名称]ポリマー組成物

特開番号: JP-2022157235-A
公開日: 2022/10/14

6. [発明の名称]コンタクトレンズ用保存液

特開番号: JP-2022151117-A
公開日:2022/10/7
[発明の名称]隐形眼镜用保存液
特開番号: CN-115125066-A
公開日:2022/9/30

7. [発明の名称]医療用組成物及びその用途

特開番号: WO-2022210938-A1
公開日: 2022/10/6

8. [発明の名称]組成物および硬化膜付き医療器具

特許番号: JP-7129071-B2
特許発行日: 2022/9/1
[発明の名称]組成物および硬化膜付き医療器具
特開番号: WO-2020153270-A1
公開日: 2020/7/30
[発明の名称]Composition and medical device with cured film
特開番号: US-20210332239-A1
公開日: 2021/10/28

9. [発明の名称]Medical device with composition and cured film

特許番号: JP-7129071-B2特許番号: JP-7129071-B2
特許発行日: 2022/9/1
[発明の名称]Composition and medical device with cured film
特開番号: US-20210332239-A1
公開日: 2021/10/28

10. [発明の名称] 特定細胞捕捉方法

特許番号: JP-7109719-B2
特許発行日: 2022/8/1
[発明の名称] Method for capturing specific cells
特開番号: US-20190250150-A1
公開日: 2019/8/15

その他出願・登録あり。

D. その他の活動（プレスリリース・新聞記事等・広報資料）

1. 生体親和性の科学を解き明かす 田中賢教授

（九州大学RESEARCH CLOSE-UP 2022年5月17日）
https://www.kyushu-u.ac.jp/ja/research/close-up/masaru-tanaka